I soon discovered that I was quite isolated in my attempts to pursue the sociology of literature. In any case, one searched almost in vain for allies if one wanted to approach a literary text from the perspective of a critical theory of society. To be sure, there were Franz Mehring’s articles which I read with interest and profit; but despite the admirable decency and the uncompromising political radicalism of the author, his writings hardly went beyond the limits of a (...) socialist journalist who wrote in essentially the same style about literature as about political and the economy. George Lukács had not yet published his impressive series of essays on Marxist aesthetics and interpretation of literature. Of course, I was deeply touched and influenced by his fine little book, The Theory of the Novel , which I practically learned by heart. Besides Levin Schücking’s small volume on the sociology of literary taste, the only other major influence I can recall was George Brandes’ monumental work on the literary currents of the nineteenth century.Nonetheless, I had the courage, not to say hubris, to plan an ambitious, socially critical series on French, English, Spanish, and German literature, the beginning of which was to be formed by the above-mentioned studies. My attention was especially focused on the writes and literary schools which the German literary establishment either punished by total silence or raised up into the clouds of idealistic babble or relegated to quasi-folkloric anthropology .In these studies, I limited myself to the narrative forms of literature; for reasons which I hold to be sociologically and artistically valid, I believe that novels and stories represent the most significant aspect of German literature in the nineteenth century. While I in no way feel ashamed of these documents of my youth, I am conscious of their weaknesses. If I were to write them over again, I would certainly be less sure of some of the direct connections I drew between literature and writers on the one hand, and the social infrastructure on the other. In later publications I attempted to analyze with greater circumspection the mediation between substructure and superstructure, between social currents and ideologies; but my views on the social world and the necessity to combine social theory and literary analysis have not changed in any essential way. In the last decades the sociology of literature has become progressively more fashionable. The writings of my contemporaries have often amazed me because some—frequently in unnecessarily complicated and esoteric language—are so concerned with “mediation” that the connections between social being and social consciousness became almost obscured. Leo Lowenthal is professor emeritus of sociology at the University of California, Berkeley. He is also professor emeritus at the University of Frankfurt in West Germany. His collected works have been published in five volumes in German and in a parallel English edition. Lowenthal’s autobiographical writings, edited by Martin jay, will appear in the fall of 1987 under the title An Unmastered Past. Lowenthal’s present studies deal with German postmodernism. Ted. R. Weeks is a graduate student at the University of California, Berkeley, specializing in imperial Russian history. (shrink)

Book reviewed in this article: Ethical Issues in Social Research. Edited by Tom L. Beauchamp, Ruth R. Faden, R. Jay Wallace, Jr., and LeRoy Walters. Baltimore: The Johns Hopkins University Press, 1982. xii + 436 pp. $25.00 (hardcover); $8.95 (paper). Ethics of Human Subject Research. Edited by Allan J. Kimmel, Jr. San Francisco: Jossey‐Bass, 1981. 106 pp. $6.95 (paper). Social Research Ethics. Edited by Martin Bulmer. New York: Holmes & Meier, 1982. xiv + 284 pp. $39.50 (hardcover); $14.50 (paper). The (...) Ethics of Social Research: Field‐work, Regulation and Publication. Edited by Joan E. Sieber. New York: Springer‐Verlag, 1982. x + 187 pp. $23.50 (hardcover). The Ethics of Social Research: Surveys and Experiments. Edited by Joan E. Sieber. New York: Springer‐Verlag, 1982. xii + 249 pp. $23.50 (hardcover). (shrink)

Book reviewed in this article: Ethical Issues in Social Research. Edited by Tom L. Beauchamp, Ruth R. Faden, R. Jay Wallace, Jr., and LeRoy Walters. Baltimore: The Johns Hopkins University Press, 1982. xii + 436 pp. $25.00 (hardcover); $8.95 (paper). Ethics of Human Subject Research. Edited by Allan J. Kimmel, Jr. San Francisco: Jossey‐Bass, 1981. 106 pp. $6.95 (paper). Social Research Ethics. Edited by Martin Bulmer. New York: Holmes & Meier, 1982. xiv + 284 pp. $39.50 (hardcover); $14.50 (paper). The (...) Ethics of Social Research: Field‐work, Regulation and Publication. Edited by Joan E. Sieber. New York: Springer‐Verlag, 1982. x + 187 pp. $23.50 (hardcover). The Ethics of Social Research: Surveys and Experiments. Edited by Joan E. Sieber. New York: Springer‐Verlag, 1982. xii + 249 pp. $23.50 (hardcover). (shrink)

Patient safety has only recently been subjected to wide-spread systematic study. Healthcare differs from other high risk industries in being more diverse and multi-contextual, and less certain and regulated. Also many patient safety problems are low-frequency events associated with many, varied contributing factors. The subject of this paper is the epistemology of patient safety (the science of the method of finding out about patient safety). Patient safety research is considered here on the background of a risk management framework which requires (...) researchers to: • Understand the context - as a subset of healthcare quality, services and systems research, with technical and human behavioural (cultural) components and a range of external and internal organisational influences, a wide range of research disciplines is necessary • Identify the risks - identify the things that go wrong and the frequency and nature of different types of incidents from sources such as medical record review, observational studies, audit, incident and medico-legal reports • Analyse the risks - deconstruct the things that go wrong, identifying contributing factors and trying to detect trends and patterns in contributing factors, detection, mitigation factors, ameliorating factors and actions taken to reduce risk • Evaluate the risks - decide on priorities, identifying preventive and corrective strategies and judging the risk- and cost-benefit of potential corrective strategies such as standardisation or simplification of a process or device • Manage the risk - evaluate and scope preventive and/or corrective strategies and then implement these, or place the problem on a risk register pending solution, or accept that what is needed is unaffordable • Communicate and consult - use interactive sessions, audit, on-going feedback, reminders and patient mediated prompts • Monitor and review the state of the problem - get baseline trends and patterns so that changes can be tracked and properly attributed to an intervention A hierarchy of levels of evidence has been proposed for clinical research and we argue that insufficient weighting has been given to lower ranked levels of research and to qualitative research, although critical interpretive synthesis is now gaining acceptance in mainstream thinking (e.g. by the Cochrane Collaboration). Fundamental challenges remain including how to grasp the elusive concept of patient safety, how to quantify, characterise and cost the problems, how to judge the extent to which harm can be attributed to errors, violations or system failures, how to identify contributing factors and the extent to which they can be implicated, how to judge whether incidents or their precursors are preventable, how to generate strong evidence to make healthcare safer and how to translate research into practice. Future directions include addressing the mundane as well as rare, dramatic events, and developing further research in non-hospital settings and in developing countries. In summary, a mixture of qualitative and quantitative methods, using information from all available data sources and combining retrospective, real time and prospective study designs, is necessary to address some of the more difficult patient safety problems. (shrink)

Growth cones are the highly motile structures found at the tips of growing axons and dendrites (neurites), which extend from neurones, during the development of the nervous system. They function both as detectors and transducers of extrinsic guidance cues and as regions where the neurite cytoskeleton is assembled. Without concerted neurite assembly, advance cannot occur. Assembly of the neurite cytoskeleton in growing neurites chiefly involves microtubule assembly at the growth cone. Some of the factors that may influence microtubule assembly in (...) growth cones are becoming apparent and include posttranslational modification of tubulin itself and microtubule associated proteins, particularly tau and MAP1B. (shrink)

We asked whether and how generations vary in their perceptions on moral matters ranging from their justifications of crime and questions concerning bodily autonomy. In our exploratory study using data from the World Values Survey, we found that Generations Y and Z are more likely than their older counterparts to justify crimes, such as cheating on taxes or stealing property, and to favor greater bodily autonomy in issues such as suicide and abortion. They also rank lower the importance of God (...) and national pride. Implications are offered for employers who wish to motivate and incentivize a multi-generational workforce. (shrink)

Strangers to Nature brings together many of the leading scholars who are working to redefine and expand the discourse on animal ethics. This volume will engage both scholars and lay-people by revealing the breadth of theorizing about the human/non-human animal relationship that is currently taking place.

Evidence that placebo acupuncture is an effective treatment for chronic pain presents a puzzle: how do placebo needles appearing to patients to penetrate the body, but instead sitting on the skin’s surface in the manner of a tactile stimulus, evoke a healing response? Previous accounts of ritual touch healing in which patients often described enhanced touch sensations suggest an embodied healing mechanism. In this qualitative study, we asked a subset of patients in a singleblind randomized trial in irritable bowel syndrome (...) to describe their treatment experiences while undergoing placebo treament. Analysis focused on patients’ unprompted descriptions of any enhanced touch sensations and any significance patients assigned to the sensations. We found in 5/6 cases, patients associated sensations including “warmth” and “tingling” with treatment efficacy. The conclusion offers a “neurophenomenological” account of the placebo effect by considering dynamic effects of attentional filtering on early sensory cortices, possibly underlying the phenomenology of placebo acupuncture. (shrink)

The late J. L. Mackie and his work were a focus for much of the best philosophical thinking in the Oxford tradition. His moral thought centres on that most fundamental issue in moral philosophy – the issue of whether our moral judgements are in some way objective. The contributors to this volume, first published in 1985, are among the most distinguished figures in moral philosophy, and their essays in tribute to John Mackie present views at the forefront of the subject. (...) Five of the essays give a new understanding of the objectivity of moral judgements. These are by Simon Blackburn, R.M. Hare, John McDowell, Susan Hurley and Bernard Williams. The remaining contributors – Philippa Foot, Steven Lukes, Amartya Sen, David Wiggins – give their attention to problems which are equally compelling, such as the defence of a moral outlook based on a conception of a need and of what follows from it. The volume also includes the addresses given by Simon Blackburn and George Cawkwell at the memorial service for John Mackie, and a list of his publications, compiled by Joan Mackie. (shrink)

Chalmers (The character of consciousness, 2010) argues for an acquaintance theory of the justification of direct phenomenal beliefs. A central part of this defense is the claim that direct phenomenal beliefs are cognitively significant. I argue against this. Direct phenomenal beliefs are justified within the specious present, and yet the resources available with the present ‘now’ are so impoverished that it barely constrains the content of a direct phenomenal belief. I argue that Chalmers’s account does not have the resources for (...) explaining how direct phenomenal beliefs support the inference from ‘this E is R’ to ‘that was R.’. (shrink)

We propose a naturalistic version of the “guesser–knower” paradigm in which the experimental subject has an opportunity to choose which individual to follow to a hidden food source. This design allows nonhumans to display the attribution of knowledge to another conspecific, rather than a human, in a naturalistic context (finding food), and it is readily adapted to different species.

This chapter contains sections titled: Introduction The Logic of Freedom The Logic of Denial Conclusion.

The late J. L. Mackie and his work were a focus for much of the best philosophical thinking in the Oxford tradition. His moral thought centres on that most fundamental issue in moral philosophy – the issue of whether our moral judgements are in some way objective. The contributors to this volume, first published in 1985, are among the most distinguished figures in moral philosophy, and their essays in tribute to John Mackie present views at the forefront of the subject. (...) Five of the essays give a new understanding of the objectivity of moral judgements. These are by Simon Blackburn, R.M. Hare, John McDowell, Susan Hurley and Bernard Williams. The remaining contributors – Philippa Foot, Steven Lukes, Amartya Sen, David Wiggins – give their attention to problems which are equally compelling, such as the defence of a moral outlook based on a conception of a need and of what follows from it. The volume also includes the addresses given by Simon Blackburn and George Cawkwell at the memorial service for John Mackie, and a list of his publications, compiled by Joan Mackie. (shrink)

The ArgumentJohann von Justi, the foremost literary cameralist of his generation, served as chief police commissioner in Göttingen between 1755 and 1757. While in Göttingen, Justi offered lectures at the university on the “œconomic, police and cameral sciences.” He also arrested vagrants, wrote on chemistry, disciplined unruly students, conducted chemical experiments, supervised the pricing of Göttingen's staple goods, engaged in a public controversy with a prominent Berlin chemist, edited and published a bi-weekly periodical (Göttingische Policey-Amts Nachrichien), and worked with the (...) university's curator to refashion the academic structure of the sciences. Taken together, these various activities reflected his broad vision for social and academic change, a vision with important implications for the form and content of the sciences. Drawing on archival material in Göttingen, on articles from thePolicey-Amts Nachrichten, and on Justi's other cameralist and chemical writings, I use his everyday experiences as a local police official to explore the meaning of his chemical work. I argue that Justi's chemistry was suffused with the cameralist dreams and ambitions of a small-town police commissioner. It is what I call police chemistry. (shrink)

Revisionism in the theory of moral responsibility is, roughly, the idea that some aspect of our responsibility practices, attitudes, or concept is in need of revision. In this paper, I argue that (1) in spite of being an increasingly prevalent thread in discussions of moral responsibility, revisionism is poorly understood, (2) the limited critical discussion there has been of it does not reflect the complexities and nuances of revisionist theories, and (3) at least one species of revisionismmoderate revisionism- has some (...) advantages over conventional compatibilist and incompatibilist theories. If I am right, one result is that the outcome of prominent debates about the compatibility (or not) of determinism and our commonsense thinking about moral responsibility may be less crucial than they seem. (shrink)

Surely [John R.] Searle must rely on a stable, formal conception of the point of view. He sets Las Meninas on a par with the antimony of the liar and the paradoxes of set theory. But nothing is an antimony or a paradox just because it seems so or just because it is confusing or difficult, even if it seems so to everyone. To deserve such a description, a thing must be, so to speak, intrinsically intractable, not merely resistant when (...) looked at in a particular way. If a man says "I do not believe I am alive," that would be odd, and it would be hard to understand just what he means, and it may even be hard or impossible to believe that he is telling the truth; but there is no antimony. If a man says "I am lying," then we have a primitive version of the antimony of the liar. Given the meaning of this utterance—and nothing else—there is no way to get a grip on it. If what the man says is true, then it's false; if what he says is false, then it's true. Joel Snyder, a practicing photographer, is associate professor of humanities and of art and design at the University of Chicago. His contributions to Critical Inquiry include "Photography, Vision, and Representation," written with Neil Walsh Allen , and "Picturing Vision" . Ted Cohen, associate professor of philosophy at the University of Chicago, has written on language, aesthetics, and taste. His previous contribution to Critical Inquiry, "Metaphor and the Cultivation of Intimacy," appeared in the Autumn 1978 issue. (shrink)

Female coital orgasm may be an adaptation for preferentially retaining the sperm of males with “good genes.” One indicator of good genes may be physical attractiveness. Accordingly, R. Thornhill, S. W. Gangestad, and R. Comer (1995) found that women mated to more attractive men reported an orgasm during a greater proportion of copulations than did women mated to less attractive men. The current research replicates this finding, with several design variations. We collected self-report data from 388 women residing in the (...) United States or in Germany. Results support the hypothesis that women mated to more attractive men are more likely to report an orgasm at the most recent copulation than are women mated to less attractive men, after statistically controlling for several key variables. Discussion addresses (a) the inability of the present research to specify the causal link between female orgasm and male attractiveness and (b) the proactive nature of female sexuality documented in recent research guided by an evolutionary perspective. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 183 Moore goes on to provide an analysis, all of which goes to support the contentions (1) that, except in philosophy, there is no puzzle ("In the first place: Are you puzzled?...I am in a way, in spite of all the Critical Phil. I've done. But I'm not sure my puzzlement is all of the sort B. means: it seems such a queer question to ask: Why (...) should you ask it?"); (2) if there is a problem it exists within a philosophical theory, as in Russell's Analysis o] Matter, and that what "Critical Phil. really can do is to explain why R. is wrong when he says this"; and (3) "If you don't find that question interesting, I think you'd better not do Crit. Phil." (p. 170). Curious stuff for Part I Moral Science Tripes takers; one wonders how many of them decided they weren't that interested in the question as to whether the theories of Broad or Ru~ell were true or false, or just plain silly. Perhaps this suffices to show that the characteristic mood of Moore's public writings is to be found in the lectures as well. Somehow or other, students were exposed to this cold bath of scepticism as to the significance of the whole endeavor, and yet went on to caxry out, in his own sytle, those rather more dogmatic exercises in analysis for which he is famous. This curious combination of dogmatic claim and lingering doubt suffuses Moore's work, of course. Perhaps it is seen best here in his ready acceptance of a method in which problems will be resolved by showing what is entailed by what we say, yet admitting that in most cases how you decide that p entails q is not terribly clear. All in all this is a valuable extension of a portrait of a major figure in twentieth century philosophy; and Mr. Lewy is to be congratulated for his skillful editing, conveying the arguments while preserving the quality of Moore's mind. At the same time there is something a bit depressing about it all, something a little too arrogant about the insistence that the stuff he is doing has no significance apart from what other moral science lecturers are saying to other crowds of undergraduates and writing for other lecturers in moral science. A. R. LoucH Ctar~faont Graduate School ~ant et le Kantisme. By Jean Lacroix. (Paris: Presses Universitairesde France, 1966.Pp. 127. -~ "Que Sais-je?", 1213.) Lacroix' Kant et ~e Kantisme is a concise, well argued defense of two theses: 1) The main import of Kant's work is metaphysical. 2) Kant's Critical programme derived its impetus from the desire to insure human freedom, morality, and religion against the fatalism or scepticism to which Kant felt Leibniz' and Wolff's dogmatic metaphysics or Hume's naturalism condemned them. The approach is not altogether new, particularly in Europe, but it has been largely overlooked in the United States and Britain. There are exceptions, such as Lewis White Beck, but generally English speaking philosophers have contended that Kant's motives were mainly epistemological. Lacroix argues that the three Critiques are parts of a single philosophical conception of man's place in the universe. Although his book is short, directed at the general (French) reader, and therefore necessarily concerned with the broad flow of Kant's thought, he does an admirable job of marshalling evidence from all the main works in the Kantian corpus, including the Opus Postumum. In the last, according to Lacroix, "... Kant a voulu ]ui-m~me synthdtiser les diverses Critiques et donner une rue d'ensemble de sa pens~e" (p. 9). The reader will, however, feel frustrated with Lacroix' documentation, for all the citations are to French translations, making them difficult to follow up. Inasmuch as Lacroix has a penchant for citing particularly pregnant passages and has written a book worthy of consideration by serious students of Kant, correlate citations to the Akademie Ausgabe are warranted. The weight of Lacroix' thesis that Kant's intentions were primarily metaphysical rests on his contention that "... le noum~ne a aussi un rble positif" (p... (shrink)

This collection opens a dialogue between process philosophy and contemporary consciousness studies. Approaching consciousness from diverse disciplinary perspectives—philosophy, psychology, neuroscience, neuropathology, psychotherapy, biology, animal ethology, and physics—the contributors offer empirical and philosophical support for a model of consciousness inspired by the process philosophy of Alfred North Whitehead (1861–1947). Whitehead’s model is developed in ways he could not have anticipated to show how it can advance current debates beyond well-known sticking points. This has trenchant consequences for epistemology and suggests fresh and (...) promising new perspectives on such topics as the mind-body problem, the neurobiology of consciousness, animal consciousness, the evolution of consciousness, panpsychism, the unity of consciousness, epiphenomenalism, free will, and causation. Contents: Introduction, Michel Weber & Anderson Weekes I. Setting the Stage 1. Process Thought as a Heuristic for Investigating Consciousness, Michel Weber & Anderson Weekes 2. Whitehead as a Neglected Figure of 20th Century Philosophy, Michel Weber & Anderson Weekes 3. Consciousness as a Topic of Investigation in Western Thought, Anderson Weekes 4. Whitehead’s Unique Approach to the Topic of Consciousness, Anderson Weekes II. Psychology and Philosophy of Mind 5. Consciousness as a Subjective Form, David Ray Griffin 6. The Interpretation and Integration of the Literature on Consciousness from a Process Perspective, Michael W. Katzko 7. Windows on Nonhuman Minds, Donald R. Griffin III. From Metaphysics to (Neuro)Science and Back Again 8. Panexperientialism, Quantum Theory, and Neuroplasticity, George W. Shields 9. The Evolution of Consciousness, Max Velmans 10. The Carrier Theory Of Causation, Gregg H. Rosenberg IV. Clinical Applications: Consciousness as Process 11. The Microgenetic Revolution in Contemporary Neuropsychology and Neurolinguistics, Maria Pachalska and Bruce Duncan MacQueen 12. From Coma to Consciousness, Avraham Schweiger, Michael Frost, Ofer Keren 13. Consciousness and Rationality from a Process Perspective, Michel Weber V. History (and Future?) of Philosophy 14. Consciousness, Memory, and Recollection according to Whitehead, Xavier Verley 15. Consciousness and Causation in Light of Whitehead’s Phenomenology of Becoming, Anderson Weekes. (shrink)

Rita Bottino,1 Santosh Nagaraju,2 Vikas Satyananda,2 Hidetaka Hara,2 Martin Wijkstrom,2 Massimo Trucco,1 David KC Cooper2 1Institute of Cellular Therapeutics, Allegheny Health Network, 2Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA: Diabetes mellitus is increasing worldwide. Type 1 diabetes can be treated successfully by islet allotransplantation, the results of which are steadily improving. However, the number of islets that can be obtained from deceased human donors will never be sufficient to cure more than a very (...) small percentage of patients who might benefit from transplantation. Although there are some differences in glucose metabolism between pigs and humans, the use of pigs could provide an unlimited supply of islets, and the insulin produced would undoubtedly control glucose levels. Transplantation of islets into the portal vein results in islets residing in the liver; however, an early inflammatory response and rejection remain problematic, even when the recipient is receiving immunosuppressive therapy. In the long term, immunosuppressive drugs may exhibit toxicities to patients and specifically harm the islet cells. In contrast, encapsulation techniques provide islets with a physical barrier that prevents antibodies binding to the islet graft while still allowing insulin to be released into the recipient's circulation; in theory, patients receiving encapsulated grafts might not require exogenous immunosuppressive therapy. Nonhuman primates with encapsulated pig islet transplants have remained insulin-independent for several weeks, but long-term efficacy remains uncertain. Furthermore, techniques are now available to knock out genes from the pig and/or insert human genes, thus rendering the antigenic structure of pigs closer to that of humans, and providing protection from the human immune response. Islet transplantation from genetically engineered pigs has been followed by insulin independence in a small number of nonhuman primates for greater than 1 year. Neonatal islets have some advantages over adult islets in that they are easier to isolate and culture, and have the ability to proliferate during the first few months after transplantation. In 2009, the International Xenotransplantation Association set up a group to encourage and advise on clinical trials of pig islet xenotransplantation; this group's guidelines are discussed. Clinical trials of encapsulated pig islets are already under way. Keywords: diabetes, islets, pancreatic, pig, xenotransplantation. (shrink)